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PEBP1 polyclonal antibody（KU）

货号: BS5912

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS5912

Product Name :PEBP1 polyclonal antibody（KU）

Swiss-Prot :P30086

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB ICC

Application_all :WB: 1:500~1:1000 ICC: 1:50~1:200

Background :Raf kinase inhibitor protein (RKIP) is a cytosolic protein that was initially characterized as a phosphatidylethanolamine-binding protein (PBP) expressed in brain tissue and secreted from testis fluid. In addition, RKIP was identified by yeast two-hybrid screening of human T cell libraries directed at identifying proteins that associate with the BXB kinase domain of the serine/threonine kinase, Raf-1. Subsequent in vitro and in vivo studies indicate that RKIP binds to both the active and inactive forms of Raf-1 and thereby regulates the signaling cascade of the MAP kinase pathway. The specific association of RKIP with kinase-active Raf-1 competitively inhibits the binding and activation of the Raf-1 substrate MEK. RKIP, in turn, affects downstream MAP kinase signaling by decreasing the activation of MEK effector proteins, including ERK1 and ERK2, and the subsequent induction of AP-1 mediated transcription.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PEBP1 polyclonal antibody detects endogenous levels of PEBP1 protein.

BiowMW :~ 21 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Phosphatidylethanolamine-binding protein 1; PEBP-1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP; Hippocampal cholinergic neurostimulating peptide; HCNP; PBP; PEBP

Immunogen :Synthetic peptide, corresponding to amino acids 142-187 of Human PEBP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RKIP (L138) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate(40ug) Lane2:The Testis tissue lysate of Rat(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug)