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Rho D polyclonal antibody

货号: BS5898

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5898

Product Name :Rho D polyclonal antibody

Swiss-Prot :O00212

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB ICC IP

Application_all :WB: 1:500~1:1000 ICC: 1:50~1:200 IP: 1:50~1:200

Background :Upon activation, the small GTPase Rho D (also designated RhoHP1 and ARHD) contributes to rearrangement of the actin cytoskeleton and cell surface and also governs endosome motility and distribution. The effects of Rho D antagonize those of its family member, Rho A, by dissasembling actin stress fibers normally enhanced by Rho A. Additionally, Rho D disengages focal adhesions, resulting in retardation of cell migration. Accordingly, transfection of a constitutively active form of Rho D (designated Rho D G26V) reverses the invasive phenotype of Gαolf induced cells, implying the possiblity of a therapeutic use for activated Rho D in counteracting tumor metastasis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Rho D polyclonal antibody detects endogenous levels of Rho D protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1; RHOD; ARHD

Immunogen :Synthetic peptide, corresponding to amino acids 156-201 of Human Rho D.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Rho D polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）