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PKN1 polyclonal antibody

货号: BS5859

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS5859

Product Name :PKN1 polyclonal antibody

Swiss-Prot :Q16512

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB ICC

Application_all :WB: 1:500~1:1000 ICC: 1:50~1:200

Background :Protein kinase N (PKN) is a fatty acid-activated serine/threonine kinase whose catalytic domain exhibits homology with that of the PKC family. PKN associates with Rho via its amino terminus, is activated in a GTP-dependent manner and phosphorylates the head-rod domain of neurofilament protein. A second protein, rhophilin, exhibits 40% sequence identity with the amino terminal Rho binding domain. The enzymatic activity of rhophilin has not been demonstrated and it is possible that it acts through the recruitment of cytoskeletal components that initiate a kinase signaling cascade. Citron interacts specifically with active Rho and Rac1 but not Cdc42. Citron exhibits a distinctive protein organization and little homology with the Rho binding domains of PKN and rhophilin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PKN1 polyclonal antibody detects endogenous levels of PKN1 protein.

BiowMW :~ 103, 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein kinase N1; Protease-activated kinase 1; PAK-1; Protein kinase C-like 1; Protein kinase C-like PKN; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; Serine-threonine protein kinase N; PAK1; PKN; PRK1; PRKCL1

Immunogen :Synthetic peptide, corresponding to amino acids 294-339 of Human PKN1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PKN1 polyclonal antibody at 1:500 dillution Lane1:MCF-7 whole cell lysate(40μg) Lane2:AML-12 whole cell lysate(40μg) Lane3:BV2 whole cell lysate(40μg) Lane4:C6 whole cell lysate(40μg) Lane5:H9C2 whole cell lysate(40μg)