产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

PBR polyclonal antibody

货号: BS5840

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5840

Product Name :PBR polyclonal antibody

Swiss-Prot :P30536

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:2000

Background :Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PBR polyclonal antibody detects endogenous levels of PBR protein.

BiowMW :~ 18, 30, 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; TSPO; BZRP; MBR

Immunogen :Synthetic peptide, corresponding to amino acids 124-169 of Human PBR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PBR pAb at 1:2000 dilution Lane1:PMVEC whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:3T3-L1 whole cell lysate(40ug) Lane4:A2780 whole cell lysate(40ug) Lane5:A549 whole cell lysate(40ug)

MiR-202 promotes endometriosis by regulating SOX6 expression

JournalInternational Journal of Clinical and Experimental Medicine

ApplicationIHC

IF0.166

SpeciesHuman

PMID26770366