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MRP-S12 polyclonal antibody（KU）

货号: BS5803

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5803

Product Name :MRP-S12 polyclonal antibody（KU）

Swiss-Prot :O15235

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-S12 (mitochondrial ribosomal protein S12) is a 138 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 28S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. In response to mitochondrial stress, bidirectional MRP-S12 promoter activity is strongly stimulated, an event that happens to correlate with mitochondrial reactive oxidative species (ROS) production. Due to its specific location on human chromosome 19, the gene encoding MRP-S12 may be a candidate gene for susceptibility to aminoglycoside ototoxicity and for the autosomal dominant deafness gene DFNA4.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MRP-S12 polyclonal antibody detects endogenous levels of MRP-S12 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :28S ribosomal protein S12, mitochondrial; MRP-S12; S12mt; MT-RPS12; MRPS12; RPMS12; RPSM12

Immunogen :Synthetic peptide, corresponding to amino acids 69-114 of Human MRP-S12.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MRP-S12 (K59) pAb at 1:1000 dilution Lane1:AML-12 whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug) Lane5:Hela whole cell lysate(40ug)