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Kv3.1 polyclonal antibody

货号: BS5779

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5779

Product Name :Kv3.1 polyclonal antibody

Swiss-Prot :P48547

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The human voltage-gated potassium (KV) channel KV3.1 gene maps to chromosome 11p15 and encodes a protein that resembles Drosophila Shaw subfamily channel types. KV channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KV channels are multimers that contain channel activity-dependent alpha subunits and modulatory gamma subunits. Neuronal populations in the CNS coexpressing KV3.1 and KV3.3 influence fast repolarization of action potentials and enable neurons to fire repetitively at high frequencies. KV3 genes produce multiple splice variants in the 3' ends of respective transcript, which may influence normal spatial ion permeability of excitable membranes in the brain.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Kv3.1 polyclonal antibody detects endogenous levels of Kv3.1 protein.

BiowMW :~ 58 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Potassium voltage-gated channel subfamily C member 1; NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4; KCNC1

Immunogen :Synthetic peptide, corresponding to amino acids 254-299 of Human Kv3.1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Kv3.1 polyclonal antibody at 1:500 dilution Lane1:Jurkat cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate

Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain

JournalMOLECULAR NEUROBIOLOGY

ApplicationWB,Co-IP

IF4.6

SpeciesMouse

PMID38865078