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Kv7.4 polyclonal antibody

货号: BS5773

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5773

Product Name :Kv7.4 polyclonal antibody

Swiss-Prot :P56696

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap. Mutations of KCNQ4 affect the functions of sensory outer hair cells and lead to deafness.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Kv7.4 polyclonal antibody detects endogenous levels of Kv7.4 protein.

BiowMW :~ 77 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4; KCNQ4

Immunogen :Synthetic peptide, corresponding to amino acids 650-695 of Human Kv7.4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Kv7.4 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate