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JAK2 polyclonal antibody

货号: BS5769

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5769

Product Name :JAK2 polyclonal antibody

Swiss-Prot :O60674

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.

BiowMW :~ 125 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,

Alternative Name :JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10;

Immunogen :Synthetic peptide, corresponding to amino acids 225-270 of Human JAK2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of JAK2 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate

Immunohistochemistry (IHC) analyzes of JAK2 pAb in paraffin-embedded human breast carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of JAK2 pAb in paraffin-embedded human kidney carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes

JournalOxidative Medicine and Cellular Longevity

ApplicationWB

IF5.076

SpeciesMouse

PMID32733634
Piperlongumine inhibits hepatocellular carcinoma growth by modulating GSTP1 and restraining the STAT3 signaling pathway

JournalJournal of Functional Foods

ApplicationWB

IF3.8

SpeciesHuman

PMID
Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy

Journal10.3389/fphar.2024.1393534

ApplicationWB

IF4.4

SpeciesHuman

PMID39654623