Product Name :SLC6A1 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
ICC: 1:50~1:200
Background :GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (γ-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :SLC6A1 polyclonal antibody detects endogenous levels of SLC6A1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; GABATR; GABT1; GAT1; GABA T-1; GABA T1; GABAT1;
Immunogen :Synthetic peptide, corresponding to amino acids 431-476 of Human SLC6A1.
Modification :Unmodification
