Product Name :Histone H2A.X (E145) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Histone H2A.X (E145) polyclonal antibody detects endogenous levels of Histone H2A.X protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Apoptosis,Histone Lysine Methylation Pathway,
Alternative Name :Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX;
Immunogen :Synthetic peptide, corresponding to amino acids 120-170 of Human Histone H2A.X.
Modification :Unmodification
