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Tau (phospho-S519) polyclonal antibody（KU）

货号: BS4914

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4914

Product Name :Tau (phospho-S519) polyclonal antibody（KU）

Swiss-Prot :P10636

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tau (phospho-S519) polyclonal antibody detects endogenous levels of Tau protein only when phosphorylated at Ser519.

BiowMW :~ 50-80 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Alternative Name :Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU

Immunogen :Synthetic phosphopeptide derived from human Tau around the phosphorylation site of Serine 519

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of Tau (phospho-S519) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:The Brain tissue lysate of Rat(40ug) Lane3:The Brain tissue lysate of Mouse(40ug) Lane4:HCT116 whole cell lysate(40ug)

Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum *

JournalJournal Of Biological Chemistry

ApplicationIHC

IF5.157

SpeciesMouse

PMID20516067
Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats

JournalNeurological Sciences

ApplicationWB

IF3.307

SpeciesRat

PMID24337945