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Ikaros Recombinant Rabbit mAb (KU)

货号: BS48898

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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详细信息检测数据实验指南文献

No. :BS48898

Product Name :Ikaros Recombinant Rabbit mAb (KU)

Swiss-Prot :Q13422

Host :Rabbit

Reactivity :Human

Applications :WB,ICC/IF,FC

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100

Background :This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 45 kDa; Observed MW: 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PGKA; MIG10; HEL-S-68p

Immunogen :A synthesized peptide derived from human PGK1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PGK1 in HepG2 lysates; mouse kidney lysates using PGK1 antibody.

免疫沉淀（IP）