Product Name :Shb (phospho-Y246) polyclonal antibody（KU）
Application_all :IHC: 1:50~1:200
Background :The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosinephosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf(SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-Shb (Y246) polyclonal antibody detects endogenous levels of Shb protein only when phosphorylated at Tyr246.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SH2 domain-containing adapter protein B; SHB
Immunogen :Synthetic phosphopeptide derived from human Shb around the phosphorylation site of Tyrosine 246.
Modification :Phosphorylation
