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EGFR (phospho-Y1173) polyclonal antibody

货号: BS4741

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS4741

Product Name :EGFR (phospho-Y1173) polyclonal antibody

Swiss-Prot :P00533

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, IF/ICC, IP

Application_all :WB: 1:500-1:1000 IHC: 1:50-1:100 IF/ICC: 1:50-1:100 IP: 1:50-1:100

Background :EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EGFR (phospho-Y1173) polyclonal antibody detects endogenous levels of EGFR protein only when phosphorylated at Tyr1173.

BiowMW :~ 160 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

Immunogen :KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding Y1173 of human EGFR protein.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of EGFR (Phospho-Y1173) expression in Hela (A), A549 (B) whole cell lysates.

Immunohistochemical analysis of EGFR (Phospho-Y1173) staining in human lung cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of EGFR (Phospho-Y1173) staining in HeLa cells.