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Ran Recombinant Rabbit mAb (KU)

货号: BS47298

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS47298

Product Name :Ran Recombinant Rabbit mAb (KU)

Swiss-Prot :P62826

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, ICC/IF, FC, IP

Application_all :WB: 1:1000-1:5000<br />ICC/IF: 1:50-1:200<br />FC: 1:20-1:100<br />IP: 1:20-1:50

Background :RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :24 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TC4; Gsp1; ARA24

Immunogen :A synthetic peptide of human Ran

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Ran in Jurkat,Hela,COS7,Raji cell lysates using Ran antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）