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Protein Kinase A regulatory subunit I alpha Recombinant Rabbit mAb (KU)

货号: BS47254

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :BS47254

Product Name :Protein Kinase A regulatory subunit I alpha Recombinant Rabbit mAb (KU)

Swiss-Prot :P10644

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,ICC/IF

Application_all :WB: 1:1000-1:5000<br />IHC: 1:20<br />ICC/IF: 1:20

Background :cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1

Immunogen :A synthetic peptide of human Protein Kinase A regulatory subunit I alpha

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Protein Kinase A regulatory subunit I alpha/PRKAR1A in C6,Rat Brain,Jurkat cell lysates using Protein Kinase A regulatory subunit I alpha/PRKAR1A antibody(1:500 diluted).