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VASP (phospho-S238) polyclonal antibody

货号: BS4723

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4723

Product Name :VASP (phospho-S238) polyclonal antibody

Swiss-Prot :P50552

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :VASP (vasodilator-stimulated phosphoprotein), is involved in the maintenance of cytoarchitecture by interacting with actin-like filaments. VASP shares a limited degree of homology with the amino terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP dependent kinases, VASP is phosphorylated on a regulatory serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is a protein of between 46 and 50 kDa that is highly expressed in human platelets and, like WASP, may play a role in cytoskeletal organization.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-VASP (S238) polyclonal antibody detects endogenous levels of VASP protein only when phosphorylated at Ser238.

BiowMW :~ 40, 48 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,

Alternative Name :Vasodilator-stimulated phosphoprotein; VASP

Immunogen :Synthetic phosphopeptide derived from human VASP around the phosphorylation site of Serine 238.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-VASP (S238) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with forskolin (10nM, 72h) Lane2:Raw264.7 cell lysate treated with forskolin (10nM, 72h) Lane3:PC12 cell lysate treated with forskolin (10nM, 72h)

Immunohistochemistry (IHC) analyzes of p-VASP (S238) pAb in paraffin-embedded human cervix carcinoma tissue.