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DNA Ligase IV Recombinant Rabbit mAb (KU)

货号: BS46997

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46997

Product Name :DNA Ligase IV Recombinant Rabbit mAb (KU)

Swiss-Prot :P49917

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, ICC/IF

Application_all :WB: 1:1000<br />IHC: 1:20<br />ICC/IF: 1:20

Background :The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :104 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LIG4S

Immunogen :Recombinant protein of human DNA Ligase IV

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of DNA Ligase IV in K562,U251MG,HepG2,MCF7 cell lysates using DNA Ligase IV antibody(1:500 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）