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Cullin 2 Recombinant Rabbit mAb (KU)

货号: BS46864

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46864

Product Name :Cullin 2 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q13617

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:1000-1:5000<br />IHC: 1:20<br />ICC/IF: 1:20<br />FC: 1:20<br />IP: 1:20

Background :Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :87 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CUL2; Cullin-2

Immunogen :A synthetic peptide of human Cullin 2

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Cullin 2/CUL-2 in K562,C6,3T3,Hela cell lysates using Cullin 2/CUL-2 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）