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Fas Recombinant Rabbit mAb (KU)

货号: BS46826

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46826

Product Name :Fas Recombinant Rabbit mAb (KU)

Swiss-Prot :P25445

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, ICC/IF, FC

Application_all :WB: 1:1000<br />IHC: 1:50<br />ICC/IF: 1:50<br />FC: 1:20

Background :The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6

Immunogen :A synthetic peptide of human Fas

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Fas in Hela,Jurkat cell lysates using Fas antibody(1:500 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）