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Bcr Recombinant Rabbit mAb (KU)

货号: BS46823

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46823

Product Name :Bcr Recombinant Rabbit mAb (KU)

Swiss-Prot :P11274

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:2000<br />IHC: 1:20<br />ICC/IF: 1:50<br />FC: 1:20<br />IP: 1:20

Background :A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :160 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ALL; CML; PHL; BCR1; D22S11; D22S662

Immunogen :A synthetic peptide of human Bcr

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Bcr in A549,HL-60,U2OS,C6 cell lysates using Bcr antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）