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G protein alpha 13 Recombinant Rabbit mAb (KU)

货号: BS46711

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46711

Product Name :G protein alpha 13 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q14344

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC

Application_all :WB: 1:1000-1:5000<br />IHC: 1:200

Background :Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :G13

Immunogen :A synthetic peptide of human G protein alpha 13

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of GNA13 [KO Validated] in Hela,Jurkat cell lysates using GNA13 antibody [KO Validated](1:500 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）