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Kaiso Recombinant Rabbit mAb (KU)

货号: BS46685

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46685

Product Name :Kaiso Recombinant Rabbit mAb (KU)

Swiss-Prot :Q86T24

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB: 1:1000-1:5000

Background :This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ZNF348; ZNF-kaiso

Immunogen :A synthetic peptide of human Kaiso

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Kaiso in MCF7,C6 cell lysates using Kaiso antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）