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CD19 (phospho-Y531) polyclonal antibody

货号: BS4664

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS4664

Product Name :CD19 (phospho-Y531) polyclonal antibody

Swiss-Prot :P15391

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is selectively expressed on the cell surface of B-lymphocytes, where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways. Activation of CD19 results in cross-linking of the membrane protein immunoglobulin chains and the subsequent association with Src family protein tyrosine kinases (PTK). Expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. CD19 forms functional complexes with B-lymphocyte surface proteins, including integrin β1, CD21 and CD81, which are involved in regulating B-cell development.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-CD19 (Y531) polyclonal antibody detects endogenous levels of CD19 protein only when phosphorylated at Tyr531.

BiowMW :~ 61, 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :B cell receptor signaling,

Alternative Name :B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12;

Immunogen :Synthetic phosphopeptide derived from human CD19 around the phosphorylation site of Tyrosine 531.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-CD19 (Y531) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with EGF(0.1ng/ML,30mins) Lane2:Raw264.7 cell lysate treated with EGF(0.1ng/ML,30mins) Lane3:H9C2 cell lysate treated with EGF(0.1ng/ML,30mins)