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TIP60 (phospho-S86) polyclonal antibody（KU）

货号: BS4640

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4640

Product Name :TIP60 (phospho-S86) polyclonal antibody（KU）

Swiss-Prot :Q92993

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional co-activator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ-related proteins, including MORF (MOZrelated factor) and TIP60 (TAT-interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. TIP60 was originally identified as a co-activator for the HIV TAT protein and also functions as a nuclear hormone receptor co-activator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TIP60 (phospho-S86) polyclonal antibody detects endogenous levels of TIP60 protein only when phosphorylated at Ser86.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Examples of Crosstalk Between Post-translational Modifications,Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Alternative Name :Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein; KAT5; HTATIP; TIP60

Immunogen :Synthetic phosphopeptide derived from human TIP60 around the phosphorylation site of Serine 86

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of TIP60 (phospho-S86) polyclonal antibody at 1:500 dilution Lane1:The Kidney tissue lysate of Rat(40µg) Lane2:A549 whole cell lysate(40µg) Lane3:HCT116 whole cell lysate(40µg) Lane4:CT-26 whole cell lysate(40µg)