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NCF4 Recombinant Rabbit mAb (KU)

货号: BS46289

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46289

Product Name :NCF4 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q15080

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:2000-1:10000<br />IHC: 1:50<br />ICC/IF: 1:50<br />FC: 1:20<br />IP: 1:20

Background :The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NCF; CGD3; P40PHOX; SH3PXD4

Immunogen :A synthetic peptide of human p40-phox

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of p40-phox in HL-60,U251 cell lysates using p40-phox antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）