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JAK2 (phospho-Y570) polyclonal antibody

货号: BS4610

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4610

Product Name :JAK2 (phospho-Y570) polyclonal antibody

Swiss-Prot :O60674

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-JAK2 (Y570) polyclonal antibody detects endogenous levels of JAK2 only when phosphorylated at Tyr570.

BiowMW :~ 125 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,

Alternative Name :JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10;

Immunogen :Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 570.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-JAK2 (Y570) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate Lane3:Rat kidney tissue lysate

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway

JournalJournal Of Nutritional Biochemistry

ApplicationWB

IF4.49

SpeciesPig

PMID26359029