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Snail1 (phospho-S246) polyclonal antibody

货号: BS4606

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4606

Product Name :Snail1 (phospho-S246) polyclonal antibody

Swiss-Prot :O95863

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Snail1 (phospho-S246) polyclonal antibody detects endogenous levels of Snail1 protein only when phosphorylated at Ser246.

BiowMW :~ 29 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna; SNAI1; SNAH; SNAI 1; Snail 1; Snail-1

Immunogen :Synthetic peptide, corresponding to amino acids 211-260 of Human Snail1.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of Snail1 (phospho-S246) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Immunohistochemistry (IHC) analyzes of Snail1 (phospho-S246) polyclonal antibody in paraffin-embedded human breast carcinoma tissue at 1:100.