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MLH1 Recombinant Rabbit mAb (KU)

货号: BS45788

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45788

Product Name :MLH1 Recombinant Rabbit mAb (KU)

Swiss-Prot :P40692

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:1000<br />IHC: 1:100<br />ICC/IF: 1:100<br />FC: 1:100<br />IP: 1:20

Background :The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :85 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FCC2; COCA2; HNPCC; hMLH1; HNPCC2

Immunogen :A synthetic peptide of human MLH1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts from K562, C6, 3T3, HeLa cells using db12504 at 1:1000.

免疫沉淀（IP）

免疫组织化学（IHC）