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Sonic Hedgehog Recombinant Rabbit mAb (KU)

货号: BS45732

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45732

Product Name :Sonic Hedgehog Recombinant Rabbit mAb (KU)

Swiss-Prot :Q15465

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF,FC

Application_all :WB: 1:1000-1:5000<br />IHC: 1:500-1:2000<br />ICC/IF: 1:200-1:500<br />FC: 1:20

Background :This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :50,27 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5

Immunogen :A synthetic peptide of human Sonic Hedgehog

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts from Human fetal kidney tissue using db13299 at 1:1000.

免疫沉淀（IP）

免疫组织化学（IHC）