Product Name :ALIX Recombinant Rabbit mAb (KU)
Swiss-Prot :Q8WUM4, Q9WU78, Q9QZA2
Reactivity :Human, Mouse, Rat
Applications :WB, ICC/IF, FC, IP
Application_all :WB: 1:1000<br/>ICC/IF 1:500-1:2000<br/>FC: 1:200-1:500<br/>IP: 1:20
Background :This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :AIP1; ALIX; HP95; DRIP4; MCPH29
Immunogen :Recombinant protein of human ALIX
Modification :Unmodification
