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ATF6 Recombinant Rabbit mAb (KU)

货号: BS45571

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45571

Product Name :ATF6 Recombinant Rabbit mAb (KU)

Swiss-Prot :P18850

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,IP

Application_all :WB: 1:1000<br />IHC: 1:100<br />IP: 1:20

Background :This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :90-100 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ACHM7; ATF6A

Immunogen :Recombinant protein of human ATF6

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of ATF6 in A549,HL-60,U2OS cell lysates using ATF6 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）