Product Name :ATM Recombinant Rabbit mAb (KU)
Reactivity :Human, Mouse, Rat
Applications :WB,ICC/IF,FC,IP,ChIP
Application_all :WB: 1:1000<br />ICC/IF: 1:50<br />FC: 1:100<br />IP: 1:20<br />ChIP: 1:20
Background :The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Immunogen :Recombinant protein of human ATM
Modification :Unmodification
