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BRG1 Recombinant Rabbit mAb (KU)

货号: BS45549
价格 1200
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS45549
Product Name :BRG1 Recombinant Rabbit mAb (KU)
Swiss-Prot :Q3TKT4
Host :Rabbit
Reactivity :Human, Mouse, Rat
Applications :WB,IHC,ICC/IF,FC,IP,ChIP
Application_all :WB: 1:2000-1:10000<br />IHC: 1:20-1:100<br />ICC/IF: 1:50<br />FC: 1:20<br />IP: 1:20-1:50<br />ChIP: 1:20
Background :Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :IgG
BiowMW :220 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Brg1; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo
Immunogen :A synthetic peptide of mouse BRG1
Conjugate :Unconjugated
Modification :Unmodification
Western blot detection of BRG1 in 293T,Hela,HepG2,A594 cell lysates using BRG1 antibody(1:1000 diluted).

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com