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cAMP Protein Kinase Catalytic subunit Recombinant Rabbit mAb (KU)

货号: BS45542

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45542

Product Name :cAMP Protein Kinase Catalytic subunit Recombinant Rabbit mAb (KU)

Swiss-Prot :P17612

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:2000-1:20000<br />IHC: 1:200-1:500<br />ICC/IF: 1:100-1:200<br />FC: 1:50<br />IP: 1:50

Background :This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PKACA; PPNAD4

Immunogen :A synthetic peptide of human cAMP Protein Kinase Catalytic subunit

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of cAMP Protein Kinase Catalytic subunit in K562,C6,3T3,Hela cell lysates using cAMP Protein Kinase Catalytic subunit antibody(1:1000 diluted).