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Cyclin E1 Recombinant Rabbit mAb (KU)

货号: BS45496

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45496

Product Name :Cyclin E1 Recombinant Rabbit mAb (KU)

Swiss-Prot :P24864

Host :Rabbit

Reactivity :Human

Applications :WB,ICC/IF

Application_all :WB: 1:1000-1:5000<br />ICC/IF: 1:50

Background :The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CCNE; pCCNE1

Immunogen :A synthetic peptide of human Cyclin E1

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Cyclin E1 in K562,Hela cell lysates using Cyclin E1 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）