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DDB1 Recombinant Rabbit mAb (KU)

货号: BS45489

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45489

Product Name :DDB1 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q16531

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, ICC/IF, IP

Application_all :WB: 1:2000-1:10000<br />IHC: 1:50<br />ICC/IF: 1:20<br />IP: 1:20

Background :The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :127 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1

Immunogen :A synthetic peptide of human DDB1

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of DDB1 in Hela,MCF-7,HepG2,U2OS,U251,HL-60 using DDB1 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）