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ErbB 3 Recombinant Rabbit mAb (KU)

货号: BS45473

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45473

Product Name :ErbB 3 Recombinant Rabbit mAb (KU)

Swiss-Prot :P21860

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB,IHC,FC

Application_all :WB: 1:1000<br />IHC: 1:50<br />FC: 1:20

Background :This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :185 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

Immunogen :A synthetic peptide of human ErbB 3

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of ErbB 3 in A549,MCF-7 cell lysates using ErbB 3 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）