产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Glutathione Peroxidase 1 Recombinant Rabbit mAb (KU)

货号: BS45443

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45443

Product Name :Glutathione Peroxidase 1 Recombinant Rabbit mAb (KU)

Swiss-Prot :P07203

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IHC, ICC/IF, FC, IP

Application_all :WB: 1:1000<br />IHC: 1:50<br />ICC/IF: 1:20<br />FC: 1:20<br />IP: 1:20

Background :The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GPXD; GSHPX1

Immunogen :A synthetic peptide of human Glutathione Peroxidase 1

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Glutathione Peroxidase 1 in A549,HL-60 using Glutathione Peroxidase 1 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）