产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Presenilin 2 Recombinant Rabbit mAb (KU)

货号: BS45263

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45263

Product Name :Presenilin 2 Recombinant Rabbit mAb (KU)

Swiss-Prot :P49810

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,ICC/IF,IP

Application_all :WB: 1:2000<br />IHC: 1:20<br />ICC/IF: 1:20-1:50<br />IP: 1:20

Background :Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AD4; PS2; AD3L; STM2; CMD1V

Immunogen :A synthetic peptide of human Presenilin 2

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Presenilin 2 in Rat Brain,C6,3T3,Hela cell lysates using Presenilin 2 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）