产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Securin Recombinant Rabbit mAb (KU)

货号: BS45220

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45220

Product Name :Securin Recombinant Rabbit mAb (KU)

Swiss-Prot :O95997

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, ICC/IF, FC, IP

Application_all :WB: 1:1000-1:5000<br />IHC: 1:20<br />ICC/IF: 1:20<br />FC: 1:20<br />IP: 1:20

Background :The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EAP1; PTTG; HPTTG; TUTR1

Immunogen :A synthetic peptide of human Securin

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Securin in K562,3T3,Hela cell lysates using Securin antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）