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Smad4 Recombinant Rabbit mAb (KU)

货号: BS45204

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45204

Product Name :Smad4 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q13485

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,ICC/IF,FC,IP

Application_all :WB: 1:1000<br />ICC/IF: 1:20<br />FC: 1:50<br />IP: 1:20

Background :This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :JIP; DPC4; MADH4; MYHRS

Immunogen :A synthetic peptide of human Smad4

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Smad4 in C6,Ramos using Smad4 antibody(1:1000 diluted)

免疫沉淀（IP）

免疫组织化学（IHC）