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TATA Box Binding Protein Recombinant Rabbit mAb (KU)

货号: BS45180

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45180

Product Name :TATA Box Binding Protein Recombinant Rabbit mAb (KU)

Swiss-Prot :P20226

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:1000<br />IHC: 1:500<br />ICC/IF: 1:50<br />FC: 1:50<br />IP: 1:20

Background :Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HDL4; GTF2D; SCA17; TFIID; GTF2D1

Immunogen :A synthetic peptide of human TATA binding protein TBP

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of TATA binding protein TBP in Hela,A549,HL-60,U2OS cell lysates using TATA binding protein TBP antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）