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XBP1 Recombinant Rabbit mAb (KU)

货号: BS45131

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45131

Product Name :XBP1 Recombinant Rabbit mAb (KU)

Swiss-Prot :P17861

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB,FC,IP

Application_all :WB: 1:1000<br />FC: 1:50-1:100<br />IP: 1:50

Background :This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :29, 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :XBP2; TREB5; XBP-1; TREB-5

Immunogen :Recombinant protein of human XBP1

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of XBP1 in Raw264.7 cell lysates using XBP1 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）