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Stat5 (phospho-S726/731) polyclonal antibody（KU）

货号: BS4464

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4464

Product Name :Stat5 (phospho-S726/731) polyclonal antibody（KU）

Swiss-Prot :P42229/P51692

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Stat 5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96% sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Stat5 (phospho-S726/731) polyclonal antibody detects endogenous levels of Stat5a protein only when phosphorylated at Ser726 and/or Stat5b protein only when phosphorylated at Ser731.

BiowMW :~ 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,Jak Stat ：IL-6 Receptor Signaling,T cell receptor signaling,

Alternative Name :Signal transducer and activator of transcription 5A; STAT5A; STAT5; Signal transducer and activator of transcription 5B; STAT5B

Immunogen :Synthetic peptide derived from human stat5a around the phosphorylation site of S726.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-Stat5 (S726/731) pAb at 1:500 dilution Lane1:L02 whole cell lysate(30ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:AML-12 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug)

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

JournalCell Death & Disease

ApplicationWB

IF8.469

SpeciesMouse

PMID28358365
MicroRNA‐146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury

JournalStem Cells Translational Medicine

ApplicationWB

IF5.962

SpeciesRat

PMID27400799