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TH (phospho-S8) polyclonal antibody（KU）

货号: BS4453

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4453

Product Name :TH (phospho-S8) polyclonal antibody（KU）

Swiss-Prot :P07101

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TH (phospho-S8) polyclonal antibody detects endogenous levels of TH protein only when phosphorylated at Ser8.

BiowMW :~ 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; TYH

Immunogen :Synthetic peptide derived from human TH around the phosphorylation site of S8.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-TH (S8) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:MCF-7 treated with Forskolin(4µg/ml,30 minutes) whole cell lysate(40ug) Lane3:MCF-7 treated with Forskolin(4µg/ml,60 minutes) whole cell lysate(40ug)