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PPARγ (phospho-S112) polyclonal antibody

货号: BS4444

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS4444

Product Name :PPARγ (phospho-S112) polyclonal antibody

Swiss-Prot :P37231

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-PPARγ (S112) polyclonal antibody detects endogenous levels of PPARγ protein only when phosphorylated at Ser112.

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,MTOR signaling,

Alternative Name :Peroxisome proliferator-activated receptor gamma; Short name=PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG; NR1C3; PPAR γ; PPARγ

Immunogen :Synthetic phosphopeptide derived from human PPARγ around the phosphorylation site of Serine 112.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-PPAR-γ (S112) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with colchicine Lane2:Raw264.7 cell lysate treated with colchicine Lane3:PC12 cell lysate treated with colchicine

Immunohistochemistry (IHC) analyzes of p-PPARγ (S112) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Curcumin Inhibits Transforming Growth Factor-β1-Induced EMT via PPARγ Pathway, Not Smad Pathway in Renal Tubular Epithelial Cells

JournalPLoS One

ApplicationWB

IF2.74

SpeciesHuman

PMID
Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ

JournalJournal Of Biomedical Science

ApplicationWB

IF8.41

SpeciesMouse

PMID26475357
The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria

JournalChemico-Biological Interactions

ApplicationWB

IF3.723

SpeciesRat

PMID33676887
Xeroderma Pigmentosum group D suppresses proliferation and promotes apoptosis of HepG2 cells by downregulating ERG expression via the PPARγ pathway

JournalInternational Journal Of Experimental Pathology

ApplicationWB

IF1.925

SpeciesHuman

PMID33993564