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Cdc16 (phospho-S560) polyclonal antibody（KU）

货号: BS4388

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4388

Product Name :Cdc16 (phospho-S560) polyclonal antibody（KU）

Swiss-Prot :Q13042

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle.Cdc25A, Cdc25B and Cdc25C protein Tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory Tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cdc16 (phospho-S560) polyclonal antibody detects endogenous levels of Cdc16 protein only when phosphorylated at Ser560.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6; CDC16; ANAPC6

Immunogen :Synthetic peptide derived from human Cdc16 around the phosphorylation site of S560.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Cdc16 (S560) pAb at 1:500 dilution Lane1:A375 whole cell lysate(40µg) Lane2:U-87MG whole cell lysate(40µg) Lane3:C6 whole cell lysate(40µg)