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Tuberin (phospho-T1462) polyclonal antibody（KU）

货号: BS4368

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4368

Product Name :Tuberin (phospho-T1462) polyclonal antibody（KU）

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Tuberin (T1462) pAb detects endogenous levels of Tuberin protein only when phosphorylated at Thr1462.

BiowMW :~ 220 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Immunogen :Synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Threonine 1462.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Tuberin (T1462) pAb at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug)