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TSC2 (phospho-S939) polyclonal antibody（KU）

货号: BS4367

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS4367

Product Name :TSC2 (phospho-S939) polyclonal antibody（KU）

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TSC2 (phospho-S939) polyclonal antibody detects endogenous levels of TSC2 protein only when phosphorylated at Ser939.

BiowMW :~ 220 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling,Insulin &Glucose Signaling,MTOR signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Immunogen :A synthetic peptide corresponding to residues in Human TSC2 around the phosphorylation site of Ser939.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Tuberin (S939) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:A2780 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(20ug)